Our Insights

Deep dive into critically written articles by cardiologists, unpacking the complexities and perspectives of cardiometabolics.

Insights Explorer

Beyond the Diagnosis. Think Deeper.

CardioAdvocate Insights go beyond individual conditions — editorials, practical guides, lifestyle deep-dives, and the science shaping the future of heart care. Written for patients and families who want to understand the bigger picture.

Editorials & Analysis (2 articles)

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A Step in the Right Direction

2026 ACC/AHA/NLA Dyslipidemia Guidelines — Editorial

CardioAdvocate’s analysis of the landmark 2026 cholesterol guidelines — what changed, what didn’t, and where we still disagree.

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Breaking the Loop

The Cholesterol-Inflammation Fusion Hypothesis

A new framework for understanding ASCVD — how cholesterol and inflammation form a self-reinforcing cycle, and why treating both matters.

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Conference Coverage (1 article)

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ACC 2026: CardioAdvocate Take

Late-Breaking Trials — What Changed for Your Heart

CardioAdvocate’s analysis of the 14 late-breaking trials from ACC 2026 in New Orleans — from colchicine and semaglutide to gene editing and PE treatment.

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Practical Guides (3 articles)

What Does My Calcium Score Mean?

A Patient’s Guide to CAC Score Interpretation

You got your calcium score. Now what? A plain-language guide to understanding what your number means and what to do next.

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What’s Your ApoB?

A Practical Approach to Lipid Management

Why ApoB may be the single most important number in cardiovascular prevention — and how to talk to your doctor about it.

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Who Needs to See a Specialist?

When to See a Cardiologist or Cardiometabolic Specialist

A practical guide to knowing when your cardiovascular care needs a specialist — and what to expect when you get there.

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Science & Innovation (5 articles)

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Victims of Our Own Success

HORIZON, Lp(a), and the High Bar of Modern Cardiology

HORIZON missed its primary endpoint — but that doesn’t mean Lp(a) doesn’t matter. Why the trial’s “failure” may say more about our success than the molecule.

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Peptides: Wild West or New Frontier?

GLP-1 RAs, Compounding & the Peptide Boom

FDA-approved GLP-1 receptor agonists changed medicine — but compounding pharmacies and gym peptides are a different story. What the evidence actually says.

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The Accidental Cardioprotectors

How Diabetes Drugs Became Heart Drugs

GLP-1 receptor agonists and SGLT2 inhibitors were designed for diabetes — but their cardiovascular benefits rewrote the playbook. Why that changes everything.

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Rewriting the Code

Gene Editing & Cardiovascular Medicine

CRISPR, base editing, and the future of genetic cardiovascular therapies — from one-time injections to permanent cholesterol reduction.

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Bias Is Everywhere

Cognitive Bias in Medicine

How cognitive biases shape medical decisions — and what patients can do to advocate for objective, evidence-based care.

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Lifestyle & Wellness (4 articles)

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Creatine! We’re Gonna Pump You Up!

Supplement Science

What “the best-studied supplement” actually means when you hold it to a real evidentiary standard — and what your doctor needs to know about your labs.

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A Cup of Joe Never Hurt Anyone

Coffee & Heart Health

Good news for coffee lovers — the evidence on caffeine, arrhythmias, and cardiovascular outcomes may surprise you.

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Red Red Wine, Stay Close to Me

Alcohol & Heart Health

What the “Not a Single Drop” doctrine gets wrong about alcohol, wine, and your heart — and what the evidence actually shows.

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The Wild, Wild West

Supplements & Heart Health

The unregulated world of supplements — separating evidence from marketing in the $60 billion industry.

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Getting Started (2 articles)

Start Here: CardioAdvocate

Your Guide to This Site

New to CardioAdvocate? Start here for an overview of what we do, how we organize our content, and where to find what you need.

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CardioConundrums

Interactive Case-Based Learning

Test your cardiovascular knowledge with real-world clinical scenarios — interactive cases designed to sharpen your advocacy skills.

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Explore More

Phenotype Explorer • Trusted Sources & Experts

Deep-dive into specific conditions in our Phenotype Explorer, or see who we trust in cardiovascular medicine.

Ian Riddock 10/26/26 Ian Riddock 10/26/26

Victims of Our Own Success

The first Lp(a)-lowering outcomes trial missed its mark. But a negative result in patients already on the best therapy the world has ever offered isn’t the same thing as a disproven hypothesis. The Lp(a) story has a next chapter.

Ian Riddock 10/26/26 Ian Riddock 10/26/26

Peptides: Wild West or New Frontier?

Ian Riddock 10/25/26 Ian Riddock 10/25/26

Creatine! We’re Gonna Pump You Up!

Ian Riddock 10/24/26 Ian Riddock 10/24/26

Red Red Wine, Stay Close to Me

What does the science actually say about alcohol and your heart? The answer is more nuanced than you’ve been told. From the French Paradox to modern Mendelian randomization studies, we separate myth from evidence on red wine, polyphenols, and cardiovascular health.