Going into detail on what this term means and how it relates to health guidelines. This article may be incomplete.
Thiazide diuretic most commonly used in the treatment of hypertension. Considered by many as a first line agent - extrapolated from results of the ALLHAT trial, which appeared to demonstrate preference to chlorthalidone. Subsequent JNC 7 guidelines promoted thiazide diuretics such as HCTZ as first line.